Direct (nonstop) flights from Knoxville to Chicago
2 airlines fly nonstop from Mc Ghee Tyson (TYS) to Chicago O Hare International (ORD). It's 475 miles (764 km), about 2h 2m in the air. Operated by American Airlines, United Airlines.
American Airlines
United Airlines
Route data last updated: May 28, 2026
Airlines with non-stop flights
AA
American Airlines
Alternative Routes
Other ways to fly from Knoxville to Chicago with one stop · direct emits 88 kg CO₂ per passenger
Looking for the return flight?
ORD → TYS: Flights from Chicago to KnoxvilleOther direct flights from Knoxville
Direct flights from Chicago (ORD)
Frequently Asked Questions
How long is the direct flight from Knoxville to Chicago?
A nonstop flight from Knoxville (TYS) to Chicago (ORD) takes approximately 2 hours and 2 minutes. The distance is 475 miles (764 km).
Which airlines fly nonstop from Knoxville to Chicago?
2 airlines: American Airlines, United Airlines.
Is there a nonstop flight from Knoxville to Chicago?
Yes. 2 airlines: American Airlines, United Airlines.
How far is Knoxville from Chicago?
The flight distance from Knoxville to Chicago is 475 miles (764 km), measured as the great-circle (shortest air) distance. That's roughly the same distance as Mumbai to Goa.
What type of aircraft flies from Knoxville to Chicago?
At 2h 2m, this route typically uses narrow-body or mid-range jets — Boeing 737 MAX or Airbus A320neo. Varies by airline.
What is the carbon footprint of a flight from Knoxville to Chicago?
Roughly 88 kg CO2 per passenger one-way. That's about the same as driving 440 km.
Is the return flight from Chicago to Knoxville also nonstop?
Yes — nonstop flights run both ways. Flight time may differ slightly due to wind patterns.
When is the cheapest time to fly from Knoxville to Chicago?
Midweek flights (Tue/Wed) outside holiday peaks are usually cheapest. 3-6 weeks ahead is a good window for this route. Use "Check Prices" above to compare.
How early should I arrive at Mc Ghee Tyson for this flight?
1.5-2 hours for domestic. Add more time during holidays or busy travel weekends.