There are 38 direct nonstop flight destinations from Knoxville Mc Ghee Tyson (TYS), served by 7 airlines. 38 are domestic routes and 0 are international non-stop flights. The longest direct flight goes to Las Vegas (LAS), with a non-stop flight time of 4h 18m.
Route data last updated: May 26, 2026
Most Popular from Knoxville
Busiest routes by number of airlines
🍃 Lowest-carbon direct flights from Knoxville
Shortest nonstop routes from TYS — direct flights cut takeoff/climb fuel burn vs. taking a layover
Airlines from Knoxville
About Mc Ghee Tyson (TYS)
Frequently Asked Questions
How many direct flights are there from Knoxville (TYS)?
38 nonstop destinations from Knoxville (TYS), across 7 airlines. 38 domestic, 0 international.
Which airlines fly from Knoxville (TYS)?
7 airlines fly nonstop from Knoxville (TYS). Full list is in the airline section above.
What is the longest nonstop flight from Knoxville (TYS)?
Las Vegas (LAS) — 1,739 miles, about 4h 18m.
Can I fly internationally from Knoxville (TYS)?
Check the route list above for all nonstop destinations from Knoxville (TYS).
How early should I arrive at Mc Ghee Tyson?
2 hours for domestic, 3 hours for international. Standard advice for check-in, security, and immigration.
What timezone is Knoxville (TYS) in?
America/New_York.